RESEARCH HIGHLIGHT - Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue

In this paper published in Cells, the IMPRiND team CNRS investigated α-synuclein’s (α-syn) seeding activity in tissue from the brain and enteric nervous system. Despite holding their seeding propensity in fixed brain tissues, pathogenic α-syn aggregates significant variations in the characteristics of fibrillar aggregates derived from different regions even within the same individual are reported. This finding suggests that fixation stabilises seeds with an otherwise limited seeding propensity, that yield assemblies with different intrinsic structures. This may suggest the existence of different strains within the brain of individuals suffering from PD.

This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking ( under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.

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