IMPRiND Project

Publishable summaries

IMPRiND produces annual publishable reports which describe the project achievements. They are public and and the latest can be downloaded by clicking on the links below.

IMPRiND Public Events

Below you will find information regarding public events organised by IMPRiND.

Scientific publications

Publications in peer-reviewed journals, conference proceedings, book chapters and books.
Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells.
Journal of Neurochemistry jnc.15174 (2020). doi:10.1111/jnc.15174
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions.
Acta Neuropathologica Communications 8, 133 (2020). doi:10.1186/s40478-020-00993-8
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies.
Acta Neuropathologica 139, 977–1000 (2020). doi:10.1007/s00401-020-02157-3
Structures of α-synuclein filaments from multiple system atrophy.
Nature 1–6 (2020). doi:10.1038/s41586-020-2317-6
Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons.
(Neuroscience, 2020).
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
bioRxiv 2020.01.27.921643 (2020). doi:10.1101/2020.01.27.921643
Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs.
Biophysical Journal (2020). doi:10.1016/j.bpj.2020.01.022
The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding.
Scientific Reports 10, 4895 (2020). doi:10.1038/s41598-020-61757-x
α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb.
Acta Neuropathologica Communications 7, 221 (2019). doi:10.1186/s40478-019-0859-3
Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.
eLife 8, e48907 (2019). doi:10.7554/eLife.48907
Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathy.
bioRxiv 811703 (2019). doi:10.1101/811703
Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification.
Neurobiology of Disease 129, 38–43 (2019). doi:10.1016/j.nbd.2019.05.002
The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration.
Frontiers in Immunology 10, 1139 (2019). doi:10.3389/fimmu.2019.01139
Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons.
Stem Cells International 2019, 1–15 (2019). doi:10.1155/2019/2945435
Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved.
Frontiers in Molecular Neuroscience 12, 107 (2019). doi:10.3389/fnmol.2019.00107
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.
Acta Neuropathologica (2019). doi:10.1007/s00401-019-02014-y
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature 568, 420–423 (2019). doi:10.1038/s41586-019-1026-5
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
Acta Neuropathologica (2019). doi:10.1007/s00401-019-01995-0
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network.
Stem Cell Reports (2019). doi:10.1016/j.stemcr.2018.12.007
Clustering of Tau fibrils impairs the synaptic composition of α3‐Na+/K+‐ATPase and AMPA receptors.
The EMBO Journal e99871 (2019). doi:10.15252/embj.201899871
α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.
Journal of Neurochemistry 150, 522–534 (2019). doi:10.1111/jnc.14808
How is alpha‐synuclein cleared from the cell?.
Journal of Neurochemistry 150, 577–590 (2019). doi:10.1111/jnc.14704
Structures of filaments from Pick’s disease reveal a novel tau protein fold.
Nature 561, 137–140 (2018). doi:10.1038/s41586-018-0454-y
123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson’s disease cohort versus Parkinson’s disease: 123I-FP-CIT IMAGING IN A P.A53T PD COHORT.
Movement Disorders 33, 1734–1739 (2018). doi:10.1002/mds.27451
Cryo-EM structures of tau filaments from Alzheimer’s disease.
Nature 547, 185–190 (2017). doi:10.1038/nature23002

Project Flyer

The IMPRiND project flyer describes the project at a glance. It is mainly intended as a printed product but its electronic version is available for download.

This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking ( under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.

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