In this study published in Sciences Advances, the UBx team discovered that during fibril formation in a physiological salt solution, α-syn can actually randomly adopt several amyloid folds, but several of the fibril polymorphs that emerge, were, up to now, left unnoticed. This discovery is of particular importance for the research on neurodegenerative synucleinopathies, a condition directly associated with several neurodegenerative diseases, including Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy (MSA).Read more
Emmanuelle Charpentier and Jennifer Doudna ,who pioneered the revolutionary gene-editing technology, are the winners of this year’s #NobelPrize in Chemistry. #NobelPrize2020. CRISPR gene editing is widely used for the screens in the IMPRiND project.
This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.
This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.
The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.