RESEARCH HIGHLIGHT - Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Tuesday, October 1, 2019

The observation that alpha-synuclein (α-syn) aggregates are also found in the enteric nervous system has prompted IMPRIND Partner CNRS to develop a diagnostic procedure based on the detection of pathological α-syn in gastrointestinal biopsies.

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Post-Brexit scenarios

Tuesday, October 1, 2019

Regarding the participation of British researchers in Horizon 2020 projects, UK Research and Innovation’s (UKRI) Brussels-based UK Research Office (UKRO) is maintaining and regularly updating a factsheet providing the latest information on the current situation.

If the Withdrawal Agreement is ratified before Brexit, UK participation in Horizon 2020 will be ensured until the end of the programme and for the lifetime of projects.
In the event of a no-deal scenario, different rules will apply depending on whether UK bids to EU calls have been submitted before 31 October 2019 or after.
If UK bids to EU calls have been submitted before 31 October 2019, in case of a no-deal brexit the UK government has committed to guarantee competitive UK bids to EU funding submitted before exit, even if they are notified of their success after exit, for the lifetime of the projects.
If UK bids to EU calls have been submitted after 31 October 2019, the funding for successful UK bids will be guaranteed not by the EU but by UKRI itself, which has been appointed to administer the UK’s guarantee and post-EU exit extension. The funding then will be ensured for the lifetime of such projects, even if they last beyond 2020. The UK government is seeking discussions with the European Commission to agree the details of the UK’s continued participation as a third country.
Source: Swisscore, UKRI

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RESEARCH HIGHLIGHT - It takes two to tango: Alpha-synuclein and TPPP/p25α in MSA pathogenesis

Tuesday, October 1, 2019

In this study partner BRFAA aimed to identify the mechanisms underlying the abnormal accumulation of α-syn and demonstrates for the first time that endogenous oligodendroglial α-syn, is a major component of such insoluble, highly aggregated, pathological assemblies. Their study identified endogenous oligodendroglial α-syn as a major culprit for the development of pathology in vitro and in vivo, suggests that manipulation of the expression of α-syn and/or p25α in oligodendrocytes, may provide a rationale approach to combat its accumulation and the progression of Multiple system atrophy.

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This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.

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