The observation that alpha-synuclein (α-syn) aggregates are also found in the enteric nervous system has prompted IMPRIND Partner CNRS to develop a diagnostic procedure based on the detection of pathological α-syn in gastrointestinal biopsies.Read more
Regarding the participation of British researchers in Horizon 2020 projects, UK Research and Innovation’s (UKRI) Brussels-based UK Research Office (UKRO) is maintaining and regularly updating a factsheet providing the latest information on the current situation.
In this study partner BRFAA aimed to identify the mechanisms underlying the abnormal accumulation of α-syn and demonstrates for the first time that endogenous oligodendroglial α-syn, is a major component of such insoluble, highly aggregated, pathological assemblies. Their study identified endogenous oligodendroglial α-syn as a major culprit for the development of pathology in vitro and in vivo, suggests that manipulation of the expression of α-syn and/or p25α in oligodendrocytes, may provide a rationale approach to combat its accumulation and the progression of Multiple system atrophy.Read more
This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.
This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.
The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.