RESEARCH HIGHLIGHT - Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. This work carried out by the DZNE team allows to better understand the initiation and propagation of such lesions, a key knowledge for developing therapeutics to delay or halt disease progression.

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New paper in the Molecular Neurodegeneration journal

Induced αS lesions in mouse and human brain cultures. This publication from the DZNE team shows that now we can study such lesions in a true aged human brain environment. A key finding for developing therapeutics to delay or halt disease progression.

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This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking ( under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.

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