The collaboration within IMPRiND lead to a publication on Journal of Neurochemistry untitled "
Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells".
The OMG-GOE team developed a simple laboratory model system to investigate the mechanisms leading to the aggregation and propagation of specific proteins, directly linked with two common neurodegenerative disorders, Parkinson's disease (PD) and Alzheimer's disease (AD). In this study published in Nature in July 2020, they assessed the effects of molecules on the aggregation and internalisation of tau and α-syn and identified some that can decrease α-syn and/or tau aggregation. Establishing the effects of small molecules with different chemical properties on the aggregation and spreading of α-syn and tau will be important for the development of novel therapeutic strategies.
The collaboration between the IMPRiND teams BRFAA and CNRS resulted into new and important insights into the biology of α-Syn aggregation and turnover.Read more
This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 116060. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.
This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 17.00038.
The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.